Journal
HAEMATOLOGICA
Volume 93, Issue 3, Pages 473-474Publisher
FERRATA STORTI FOUNDATION
DOI: 10.3324/haematol.11872
Keywords
chronic lymphocytic leukemia; cytogenetic diagnosis; FISH; immunoglobulin genes; hematopoietic recovery
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We report a remarkable association of recurrent (stereotyped) cytogenetic aberrations with two subsets of chronic lymphocytic leukemia (CLL) cases expressing IgG-switched, stereotyped B-cell receptors (BCRs). Comparison with cases with heterogeneous BCRs showed that these recurrent cytogenetic aberrations were subset-biased. These findings further support a role for antigen in CLL development.
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