Journal
HAEMATOLOGICA
Volume 93, Issue 3, Pages 439-442Publisher
FERRATA STORTI FOUNDATION
DOI: 10.3324/haematol.12153
Keywords
acute myeloid leukemia; nucleophosmin; NPM; mutations; antibodies; immunohistochemistry
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Funding
- Associazione Italiana per la Ricerca sul Cancro
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Acute myeloid leukemia carrying NPM1 mutations and cytoplasmic nucleophosmin (NPMc(+) acute myeloid leukemia) represents one-third of adult AML (50-60% of all acute myeloid leukemia with normal karyotype) and shows distinct biological, pathological and clinical features. We confirm in 2562 patients with acute myeloid leukemia our previous observation that NPM1 mutations and cytoplasmic nucleophosmin are mutually exclusive of recurrent genetic abnormalities. Taken together, these findings make NPMc+ acute myeloid leukemia a good candidate for inclusion in the upcoming World Health Organization classification.
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