Journal
GYNECOLOGICAL ENDOCRINOLOGY
Volume 25, Issue 4, Pages 222-234Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/09513590802571118
Keywords
Ovulation induction; pharmacogenetics; clomiphene citrate; recombinant FSH; polycystic ovary syndrome; polymorphism
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Because of an enormous increase in pharmacogenetic and -genomic knowledge, an era of predicting drug response on the basis of one's genome is drawing close to reality. Anovulation is the most common cause of infertility, and outcomes of treatment are often unpredictable. This review aims to summarise in what way genetic variability might modify effects of drug-metabolising enzymes, transporters and receptors, thereby altering response to drugs used in ovulation induction.
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