Journal
GYNECOLOGIC ONCOLOGY
Volume 130, Issue 1, Pages 162-168Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ygyno.2013.03.031
Keywords
Coping; End of life; Ovarian cancer; Psychosocial; Quality of life; Symptoms
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Funding
- Cancer Councils of New South Wales and Queensland [RG 36/05]
- U.S. Army Medical Research and Materiel Command [DAMD17-01-1-0729]
- NHMRC [400413, 400281, 199600, 211199, 457093, 496625]
- Cancer Council of NSW
- Cancer Council of QLD
- Cancer Council of SA
- Cancer Council of TAS
- Cancer Council of VIC
- Cancer Council of WA
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Objective. The aim of this study was to describe the trajectory of physical symptoms, coping styles and quality of life (QoL) and the relationship between coping and QoL over the last year of life in women with recurrent ovarian cancer. Methods. The patient cohort were women recruited to the Australian Ovarian Cancer Study who subsequently experienced recurrent, invasive ovarian cancer and completed at least one psychosocial assessment (optimism, minimisation, hopelessness/helplessness, QoL) during the last year of life (n = 217). Results. QoL declined sharply from six months before death. Lack of energy was the most prevalent symptom over three measurement periods (67-92%) and also the most severe. Anorexia (36-55%), abdominal swelling (33-58%), nausea (26-47%) and pain (26-43%) all increased in prevalence and severity towards the end of life. Higher optimism (p = 0.009), higher minimisation (p = 0.003) and lower helplessness/hopelessness (p = 0.03) at baseline were significant predictors of subsequent higher QoL. Conclusions. Progressive deterioration in quality of life may be an indicator of death within about six months and therefore should be an important consideration in decisions about subsequent treatment Coping styles which independently predicted subsequent changes in QoL could potentially be targeted by interventions to minimise worsening QoL. Crown Copyright (C) 2013 Published by Elsevier Inc. All rights reserved.
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