Journal
GYNECOLOGIC ONCOLOGY
Volume 129, Issue 2, Pages 372-376Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ygyno.2013.01.027
Keywords
In vitro fertilization; Borderline ovarian tumours; Cohort study; Hazard ratios; Risk factors; Epidemiology
Categories
Funding
- National Health and Medical Research Council, Australia [573122]
- Australian Government Department of Innovation, Industry, Science and Research
- Medical Research Council [MR/K006525/1] Funding Source: researchfish
- MRC [MR/K006525/1] Funding Source: UKRI
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Objectives. To compare the risk of borderline ovarian tumours in women having in vitro fertilization (IVF) with women diagnosed with infertility but not having IVF. Methods. This was a whole-population cohort study of women aged 20-44 years seeking hospital infertility treatment or investigation in Western Australia in 1982-2002. Using Cox regression, we examined the effects of IVF treatment and potential confounders on the rate of borderline ovarian tumours. Potential confounders included parity, age, calendar year, socio-economic status, infertility diagnoses including pelvic inflammatory disorders and endometriosis and surgical procedures including hysterectomy and tubal ligation. Results. Women undergoing IVF had an increased rate of borderline ovarian tumours with a hazard ratio (HR) of 2.46 (95% confidence interval [CI] 1.20-5.04). Unlike invasive epithelial ovarian cancer, neither birth (HR 0.89; 95% CI 0.43-1.88) nor hysterectomy (1.02; 0.24.-4.37) nor sterilization (1.48; 0.63-3.48) appeared protective and the rate was not increased in women with a diagnosis of endometriosis (HR 0.31; 95% CI 0.04-2.29). Conclusions. Women undergoing IVF treatment are at increased risk of being diagnosed with borderline ovarian tumours. Risk factors for borderline ovarian tumours appear different from those for invasive ovarian cancer. (C) 2013 Elsevier Inc. All rights reserved.
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