Journal
GYNECOLOGIC ONCOLOGY
Volume 128, Issue 2, Pages 265-270Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ygyno.2012.11.003
Keywords
Cervical; Cofactors; Epidemiology
Categories
Ask authors/readers for more resources
Objective. Co-factors for cervical cancer, including oral contraceptive (OC) use, smoking and multiparity have been identified; however, the stage at which they act in cervical carcinogenesis is not clear. We compared established risk factors among women with CIN2 and CIN3 to evaluate the heterogeneity of these factors in precancer and also assessed their role during cervical carcinogenesis. Methods. The current analysis included 2783 women with various stages of cervical disease who were enrolled in the Study to Understand Cervical Cancer Early Endpoints and Determinants (SUCCEED) and the Biopsy Study. Associations of co-factors within cervical precancer and at different stages of cervical carcinogenesis were estimated using logistic regression. Results. Long-term OC use (10 + years vs. never: OR = 2.42, 95% CI: [1.13-5.15]), multiparity (3 + births vs. nulliparous: OR = 1.54[1.04-2.28]), smoking (ever vs. never: OR = 1.95 [1.48-2.58]), and no Pap test in the previous five years (2.05 [1.32-3.17]) were positively associated with CIN3 compared to CIN2. We observed that long-term OC use, parity and smoking were associated with an increased risk of CIN3 compared to
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available