Journal
GYNECOLOGIC ONCOLOGY
Volume 116, Issue 3, Pages 295-300Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ygyno.2009.12.005
Keywords
Tumor board; Clinical trials; Gynecologic oncology; Ovarian cancer; Endometrial cancer; Cervical cancer
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Funding
- NIA NIH HHS [T32 AG023482] Funding Source: Medline
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Objective. The Tumor Board (TB) allows for an interdisciplinary approach to cancer treatment designed to encourage evidence-based treatment. However, its role in facilitating clinical trial participation has not been reported. We aimed to determine whether a prospective TB is an effective strategy for trial recruitment and to identify steps within the TB process that facilitate discussion of trial eligibility and optimize accrual. Methods. We conducted a retrospective cross-sectional analysis of women presented to Gynecologic Oncology TB between Match and December 2008. Patient demographics, TB recommendations, and post-TB patient discussions were abstracted. These were compared to data derived from the Department of Oncology Research to determine research team awareness of eligible patients and confirm trial enrollment(s). Data analysis was completed with Chi-square test; risk ratios and confidence intervals were Calculated as summary measures. Results. We reviewed 1213 case presentations involving 916 women. Overall, 358 TB recommendations (30%) identified eligible patients, of which enrollment consisted of 87 (24%) trials (6% therapeutic trials and 18% non-therapeutic trials). Compared to other types of TB recommendations, those involving trials were discussed less frequently at post-TB patient visits (79% vs. 44%). Documentation Of trial discussion at the post-TB visit was more likely to result in trial participation, versus solely relying on the research staff to communicate enrollment eligibility with the treating team (RR 2.5, p = 0.006). Conclusions. Patients identified by the TB were 2.5-times as likely to enroll in a clinical trial. but trials were mentioned only 44% of the time. Interventions that facilitate trial discussions during post-TB meetings are needed to improve trial participation. (C) 2009 Elsevier Inc. All rights reserved.
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