Journal
GYNECOLOGIC AND OBSTETRIC INVESTIGATION
Volume 75, Issue 1, Pages 9-15Publisher
KARGER
DOI: 10.1159/000343748
Keywords
Cell proliferation; Endometriosis; Gonadotropin-releasing hormone agonist; Gonadotropin-releasing hormone antagonist
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- Ministry of Education, Science, Culture, Sports and Technology of Japan
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Aims: We investigated the potential of gonadotropin-releasing hormone (GnRH) agonists and GnRH antagonists to inhibit cell proliferation in endometriotic and endonnetrial stromal cells. Methods: Twenty patients with ovarian endometriomas and 18 patients with uterine fibromas were recruited. Endometriotic and endometrial stromal cells were obtained from the ovarian chocolate cyst linings and the eutopic endometria of premenopausal women with uterine fibromas, respectively. Results: GnRH agonist or antagonist treatment attenuated tumor necrosis factor (TNF)-alpha-induced cell proliferation in the endometrial stronnal cells, whereas endometriotic stromal cells did not respond to treatment. The endonnetriotic stromal cells exhibited a decreased expression of the type I GnRH receptor compared with the endometrial stromal cells. GnRH agonists or antagonists did not repress TNF-alpha-induced IL-8 production in endometriotic stromal cells. Conclusion: GnRH agonists and antagonists have similar effects in slowing the growth of endometrial stromal cells. Endometriotic stromal cells resist the antiproliferative effect of GnRH agonists and antagonists. Copyright (c) 2012 S. Karger AG, Basel
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