4.8 Article

Innate and adaptive immune responses in chronic hepatitis B virus infections: towards restoration of immune control of viral infection

Journal

GUT
Volume 61, Issue 12, Pages 1754-1764

Publisher

BMJ PUBLISHING GROUP
DOI: 10.1136/gutjnl-2011-301073

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Funding

  1. Fondazione Cassa di Risparmio di Parma, Italy
  2. FIRB grant from the Italian Ministry of the University and Research [RBAP10TPXK]
  3. Agency of Science Technology and Research (A*STAR), Singapore

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Knowledge of the immunological events necessary to control hepatitis B virus (HBV) infection has accelerated in recent years, but their translation towards therapeutic strategies able to achieve a durable HBV suppression has been challenging. The scenario of how HBV deals with the host immunity is presented and used to discuss how the immune response can be harnessed to potentially achieve infection control.

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