Journal
GUT
Volume 61, Issue 1, Pages 135-149Publisher
BMJ PUBLISHING GROUP
DOI: 10.1136/gut.2010.233718
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Funding
- SLA Pharma AG
- MRC [G116/146] Funding Source: UKRI
- Medical Research Council [G116/146] Funding Source: researchfish
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Omega (omega)-3 polyunsaturated fatty acids (PUFAs) are naturally occurring substances that are well tolerated and have been used extensively for the prevention of cardiovascular disease. More recently, omega-3 PUFAs have been recognised to have anticancer activity. There is also evidence suggesting improved efficacy and/or tolerability of conventional cancer chemotherapy when administered with omega-3 PUFAs. The purpose of this review is to (i) describe the mechanisms by which omega-3 PUFAs are thought to have antineoplastic activity, (ii) review published preclinical and clinical studies that support anti-colorectal cancer activity and (iii) summarise current clinical trials investigating the potential therapeutic role(s) of omega-3 PUFAs at different stages of colorectal carcinogenesis, from adenoma (polyp) prevention to treatment of established malignant disease and prevention of cancer recurrence.
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