Journal
GUT
Volume 59, Issue 4, Pages 542-545Publisher
BMJ PUBLISHING GROUP
DOI: 10.1136/gut.2009.200972
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Funding
- Takeda Science Foundation
- Pancreas Research Foundation of Japan
- Uehara Memorial Foundation
- Ministry of Health, Labour and Welfare of Japan
- Grants-in-Aid for Scientific Research [21590532, 21590840] Funding Source: KAKEN
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We report a case of immunoglobulin G4 (IgG4)-related sclerosing disease involving the pancreas, liver and salivary glands. Massive infiltration of IgG4-expressing plasma cells was seen in the liver and submandibular lymph nodes. Interestingly, accumulation of IgG4-expressing plasma cells was also seen in the colon and terminal ileum. Peripheral blood mononuclear cells (PBMCs) isolated from this patient exhibited enhanced production of IgG4 and interleukin-10 upon stimulation with Toll-like receptor (TLR) ligands as compared with those from a healthy control. In contrast, production of tumour necrosis factor alpha and interferon gamma by PBMCs from this patient was markedly reduced. Since colonic mucosa is always exposed to TLR ligands derived from commensal organisms, the results of immunological studies suggest that enhanced T helper type 2 responses to intestinal microflora may underlie the immunopathogenesis in this patient with IgG4-related sclerosing disease.
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