Journal
GROWTH HORMONE & IGF RESEARCH
Volume 19, Issue 4, Pages 383-387Publisher
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.ghir.2009.04.019
Keywords
Proteomics; Mass spectrometry; SELDI-TOF; Biomarker; Growth hormone; IGF-I; HbAl; Doping
Categories
Funding
- World Anti-Doping Agency
- US Anti-Doping Agency
- Northern Sydney Central Coast Area Health Service (NSW, Australia)
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The detection of growth hormone (GH) doping is a significant problem in elite sports. GH is secreted in a pulsatile pattern from the anterior pituitary, influenced by a variety of normal and pathophysiological conditions. Exogenous recombinant hGH is virtually indistinguishable from the predominant naturally occurring isoform and is cleared from the body within 24 h. Although GH is on the World Anti-doping Agency list of banned substances, the detection of GH abuse remains challenging. This article gives an overview of the potential application of surface-enhanced laser desorption/ionization time-of-flight (SELDI-TOF) mass spectrometry to examine proteomic changes following GH administration, using both serum and white blood cell extracts as samples for analysis. Results to date indicate that proteomic changes observed following GH administration have the potential to yield novel biomarker sets for the detection of GH abuse. (C) 2009 Elsevier Ltd. All rights reserved.
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