Journal
GROWTH HORMONE & IGF RESEARCH
Volume 19, Issue 5, Pages 420-425Publisher
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.ghir.2008.12.002
Keywords
Insulin-like growth factor-1; Insulin-like growth factor binding protein-3; C-reactive protein; Men
Categories
Funding
- NCI NIH HHS [R01 CA077704-03, R01 CA077704, R01-CA770403] Funding Source: Medline
- NHLBI NIH HHS [N01-HC-48047, N01-HC-95095, N01-HC-48048, N01-HC-48049, N01HC48050, N01HC95095, N01 HC048049, N01-HC-48050, N01HC48048, N01HC48047, N01HC48049] Funding Source: Medline
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objective. Animal and human studies suggest that C-reactive protein (CRP) may be inversely associated with serum insulin-like growth factor-I (IGF-I) concentrations. However, most human studies have not controlled adequately for confounding factors, particularly nutritional intake This population-based study examined whether CRP is inversely associated with IGF-I and IGFBP-3 concentrations Methods. In cross-sectional analysis, multivariable linear regression with adjustment for age, BMI. smoking status. alcohol intake. and nutritional factors was used to relate log CRP the independent variable, to IGF-I and IGFBP-3 in a sample of black (n = 364) and white men (n = 486) separately by race Results. Only black men had positive findings: log CRP was significantly associated with IGF-I (beta= -131 ng/ml, p = 0.02) and the difference in mean IGF-I concentrations between the highest and lowest quartiles of CRP was 26 ng/ml There was a statistically significant interaction between log CRP and smoking status (p = 0.02). the regression coefficient for IGF-I predicted from log CRP was significant ill smokers (beta = 39.8 ng/ml, p = 0 0001), but not in non-smokers. The difference in mean IGF-I concentrations between highest and lowest quartiles of CRP was 100 ng/ml for black smokers. There were no associations for IGFBP-3. Conclusions: In our study, CRP levels are inversely associated with IGF-I concentrations in black male smokers: however, the causal nature of the association is unclear and Should be studied further. (C) 2008 Elsevier Ltd All rights reserved.
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