Journal
GROWTH FACTORS
Volume 31, Issue 2, Pages 57-65Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/08977194.2013.770392
Keywords
Mineralization; metabolic factors; human primary bone cells; bone metabolism
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Funding
- Progetto Ricerca Sanitaria Finalizzata, Piedmont, Italy [prot. 38097/DA2001]
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The importance of the complex interrelated regulatory pathways involving IGF factors and pancreatic hormones can be observed in several metabolic diseases, where the deregulation of these factors has a wide impact on bone health. These findings have stimulated us to compare the effect of IGF-I, IGF-II, insulin and preptin on human bone cells. The effect on cell differentiation and cell activity of osteoblasts and osteoclasts has been analysed. We have observed a significant effect by IGF-I, a modest effect by IGF-II and preptin and no effect after insulin administration on human primary osteoblast-like cells. All studied factors have shown an induction on human primary osteoclast differentiation and bone resorption activity, with IGF-I being the most potent factor. We hypothesize that these findings may be on the basis of decreased bone mass density observed in several diseases.
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