Related references
Note: Only part of the references are listed.SUMO conjugation of STAT1 protects cells from hyperresponsiveness to IFNγ
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JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
B cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans
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A Rac GTPase-Activating Protein, MgcRacGAP, Is a Nuclear Localizing Signal-Containing Nuclear Chaperone in the Activation of STAT Transcription Factors
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MOLECULAR AND CELLULAR BIOLOGY (2009)
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Stat1 Nuclear Translocation by Nucleolin upon Monocyte Differentiation
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Unphosphorylated STATs go nuclear
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CURRENT OPINION IN GENETICS & DEVELOPMENT (2008)
Role of the proteasome in modulating native G-CSFR expression
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JOURNAL OF IMMUNOLOGY (2008)
STAT3 is indispensable to IL-27-mediated cell proliferation but not to IL-27-induced Th1 differentiation and suppression of proinflammatory cytokine production
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JOURNAL OF IMMUNOLOGY (2008)
Mechanism of crosstalk inhibition of IL-6 signaling in response to LPS and TNFα
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The SOCS box of suppressor of cytokine signaling-3 contributes to the control of G-CSF responsiveness in vivo
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BLOOD (2007)
IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
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Rac1 and a GTPase-activating protein, MgcRacGAP, are required for nuclear translocation of STAT transcription factors
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The structural basis of Janus kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor
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Suppressor of cytokine signaling 1 regulates the immune response to infection by a unique inhibition of type I interferon activity
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Role of the cytokine-induced SH2 domain-containing protein CIS in growth hormone receptor internalization
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SUMO-1 conjugation selectively modulates STAT1-mediated gene responses
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BLOOD (2005)
Many good reasons to have STAT3 in the heart
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STAT3 nuclear import is independent of tyrosine phosphorylation and mediated by importin-α3
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A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
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Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis
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Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders
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Structural bases of unphosphorylated STAT1 association and receptor binding
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MOLECULAR CELL (2005)
Osteoporosis with increased osteoclastogenesis in hematopoietic cell-specific STAT3-deficient mice
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Viruses evade the immune system through type I interferon-mediated STAT2-dependent, but STAT1-independent, signaling
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IMMUNITY (2005)
SOCS2 negatively regulates growth hormone action in vitro and in vivo
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Role of tyrosine 441 of interferon-γ receptor subunit 1 in SOCS-1-mediated attenuation of STAT1 activation
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JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Both proteasomes and lysosomes degrade the activated erythropoietin receptor
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BLOOD (2005)
Stat3 dimerization regulated by reversible acetylation of a single lysine residue
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SCIENCE (2005)
Stat5 tetramer formation is associated with leukemogenesis
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CANCER CELL (2005)
A single residue modulates tyrosine dephosphorylation, oligomerization, and nuclear accumulation of stat transcription factors
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JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation
Q Gao et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
SOCS3 is a physiological negative regulator for granulopoiesis and granulocyte colony-stimulating factor receptor signaling
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JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
N-domain-dependent nonphosphorylated STAT4 dimers required for cytokine-driven activation
N Ota et al.
NATURE IMMUNOLOGY (2004)
SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granulopoiesis
BA Croker et al.
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PIAS1 selectively inhibits interferon-inducible genes and is important in innate immunity
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Inactivation of Stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiation
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Janus kinase (Jak) subcellular localization revisited -: The exclusive membrane localization of endogenous Janus kinase 1 by cytokine receptor interaction uncovers the Jak•receptor complex to be equivalent to a receptor tyrosine kinase
I Behrmann et al.
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Nucleocytoplasmic shuttling of STAT transcription factors
T Meyer et al.
EUROPEAN JOURNAL OF BIOCHEMISTRY (2004)
Regulation of STAT signalling by proteolytic processing
L Hendry et al.
EUROPEAN JOURNAL OF BIOCHEMISTRY (2004)
PIASy-deficient mice display modest defects in IFN and Wnt signaling
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Nucleocytoplasmic shuttling by nucleoporins Nup153 and Nup214 and CRM1-dependent nuclear export control the subcellular distribution of latent Stat1
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Protein inhibitor of activated STAT y (PIASy) and a splice variant lacking exon 6 enhance sumoylation but are not essential for embryogenesis and adult life
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MOLECULAR AND CELLULAR BIOLOGY (2004)
Autophosphorylation of JAK2 on tyrosines 221 and 570 regulates its activity
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MOLECULAR AND CELLULAR BIOLOGY (2004)
Tyrosine phosphorylation of Jak2 in the JH2 domain inhibits cytokine signaling
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MOLECULAR AND CELLULAR BIOLOGY (2004)
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GENOME BIOLOGY (2004)
SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Long term association of the cytokine receptor gp130 and the janus kinase Jak1 revealed by FRAP analysis
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JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
STATs dimerize in the absence of phosphorylation
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JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
DNA binding controls inactivation and nuclear accumulation of the transcription factor Stat1
T Meyer et al.
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Distinct requirements for the naturally occurring splice forms Stat4α and Stat4β in IL-12 responses
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EMBO JOURNAL (2003)
SUMO modification of STAT1 and its role in PIAS-mediated inhibition of gene activation
RS Rogers et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Activation of protein kinase Cδ by IFN-γ
DK Deb et al.
JOURNAL OF IMMUNOLOGY (2003)
Toll-like receptors 2 and 4 activate STAT1 serine phosphorylation by distinct mechanisms in macrophages
SH Rhee et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
PIASx is a transcriptional co-repressor of signal transducer and activator of transcription 4
T Arora et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
SOCS3 negatively regulates IL-6 signaling in vivo
BA Croker et al.
NATURE IMMUNOLOGY (2003)
Identification of Shp-2 as a Stat5A phosphatase
Y Chen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Autoinhibition of Jak2 tyrosine kinase is dependent on specific regions in its pseudokinase domain
P Saharinen et al.
MOLECULAR BIOLOGY OF THE CELL (2003)
SOCS-1, a negative regulator of cytokine signaling, is frequently silenced by methylation in multiple myeloma
O Galm et al.
BLOOD (2003)
STAT3 signalling is required for leptin regulation of energy balance but not reproduction
SH Bates et al.
NATURE (2003)
STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: A critical role of STAT3 in innate immunity
T Welte et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
The tyrosine kinase Tyk2 controls IFNAR1 cell surface expression
J Ragimbeau et al.
EMBO JOURNAL (2003)
PIAS/SUMO: new partners in transcriptional regulation
D Schmidt et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2003)
Epigenetic alteration of the SOCS1 gene in chronic myeloid leukaemia
TC Liu et al.
BRITISH JOURNAL OF HAEMATOLOGY (2003)
PIAS proteins promote SUMO-1 conjugation to STAT1
D Ungureanu et al.
BLOOD (2003)
The pseudokinase domain is required for suppression of basal activity of Jak2 and Jak3 tyrosine kinases and for cytokine-inducible activation of signal transduction
P Saharinen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
SHP-2 is a dual-specificity phosphatase involved in Stat1 dephosphorylation at both tyrosine and serine residues in nuclei
TR Wu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
The JAK/STAT pathway in model organisms: Emerging roles in cell movement
SX Hou et al.
DEVELOPMENTAL CELL (2002)
STATs: Transcriptional control and biological impact
DE Levy et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2002)
The fertile field of Drosophila JAK/STAT signalling
JCG Hombría et al.
CURRENT BIOLOGY (2002)
Arginine/lysine-rich nuclear localization signals mediate interactions between dimeric STATs and importin α5
R Fagerlund et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Identification of a nuclear Stat1 protein tyrosine phosphatase
J ten Hoeve et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
Androgen receptor-interacting protein 3 and other PIAS proteins cooperate with glucocorticoid receptor-interacting protein 1 in steroid receptor-dependent signaling
N Kotaja et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Stat5B shuttles between cytoplasm and nucleus in a cytokine-dependent and -independent manner
R Zeng et al.
JOURNAL OF IMMUNOLOGY (2002)
The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3
PD Simoncic et al.
CURRENT BIOLOGY (2002)
Specific ablation of Stat3β distorts the pattern of Stat3-responsive gene expression and impairs recovery from endotoxic shock
JY Yoo et al.
CELL (2002)
Par-4, a pro-apoptotic gene, inhibits radiation-induced NF kappa B activity and Bcl-2 expression leading to induction of radiosensitivity in human prostate cancer cells PC-3
D Chendil et al.
CANCER BIOLOGY & THERAPY (2002)
The N-terminal domain of Janus kinase 2 is required for Golgi processing and cell surface expression of erythropoietin receptor
LJS Huang et al.
MOLECULAR CELL (2001)
The SOCS box of suppressor of cytokine signaling-1 is important for inhibition of cytokine action in vivo
JG Zhang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Unexpected effects of FERM domain mutations on catalytic activity of Jak3: Structural implication for Janus kinases
YJ Zhou et al.
MOLECULAR CELL (2001)
Mapping of a region within the N terminus of Jak1 involved in cytokine receptor interaction
C Haan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3
AW Roberts et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Targeted and extended acetylation of histones H4 and H3 at active and inactive genes in chicken embryo erythrocytes
FA Myers et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Arginine/lysine-rich structural element is involved in interferon-induced nuclear import of STATs
K Melén et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity
H Yoshikawa et al.
NATURE GENETICS (2001)
A transcriptional corepressor of Stat1 with an essential LXXLL signature motif
B Liu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
DNA binding specificity of different STAT proteins -: Comparison of in vitro specificity with natural target sites
GB Ehret et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling
J Irie-Sasaki et al.
NATURE (2001)
Interleukin 20: Discovery, receptor identification, and role in epidermal function
H Blumberg et al.
CELL (2001)
Involvement of the ubiquitin-proteasome pathway in the degradation of nontyrosine kinase-type cytokine receptors of IL-9, IL-2, and erythropoietin
CH Yen et al.
JOURNAL OF IMMUNOLOGY (2000)
Nuclear export signal located within the DNA-binding domain of the STAT1 transcription factor
KM McBride et al.
EMBO JOURNAL (2000)
Computational and functional analysis of the putative SH2 domain in Janus Kinases
D Kampa et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2000)
Tyk2 plays a restricted role in IFNα signaling, although it is required for IL-12-mediated T cell function
K Shimoda et al.
IMMUNITY (2000)
Regulation of STAT1 nuclear export by Jak1
K Mowen et al.
MOLECULAR AND CELLULAR BIOLOGY (2000)
Partial impairment of cytokine responses in Tyk2-deficient mice
M Karaghiosoff et al.
IMMUNITY (2000)
Nucleocytoplasmic translocation of Stat1 is regulated by a leucine-rich export signal in the coiled-coil domain
A Begitt et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
A dual role for the kinase-like domain of the tyrosine kinase Tyk2 in interferon-α signaling
TC Yeh et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Gigantism in mice lacking suppressor of cytokine signalling-2
D Metcalf et al.
NATURE (2000)
Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130
SE Nicholson et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Serine phosphorylation of STATs
T Decker et al.
ONCOGENE (2000)
Regulation of the Jak2 tyrosine kinase by its pseudokinase domain
P Saharinen et al.
MOLECULAR AND CELLULAR BIOLOGY (2000)
Cytokine-induced Src homology 2 protein (CIS) promotes T cell receptor-mediated proliferation and prolongs survival of activated T cells
SL Li et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2000)
Structure of the ERM protein moesin reveals the FERM domain fold masked by an extended actin binding tail domain
MA Pearson et al.
CELL (2000)