Journal
GROWTH FACTORS
Volume 30, Issue 2, Pages 76-87Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/08977194.2012.656760
Keywords
Leukemia inhibitory factor; osteoblast; osteoclast; chondrocyte; gp130; oncostatin M
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Funding
- Victorian Government's OIS
- NHMRC (Australia)
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Leukemia inhibitory factor (LIF) is a soluble interleukin-6 family cytokine that regulates a number of physiologic functions, including normal skeletal remodeling. LIF signals through the cytokine co-receptor glycoprotein-130 in complex with its cytokine-specific receptor [LIF receptor (LIFR)] to activate signaling cascades in cells of the skeletal system, including stromal cells, chondrocytes, osteoblasts, osteocytes, adipocytes, and synovial fibroblasts. LIF action on skeletal cells is cell-type specific, and frequently dependent on the state of cell differentiation. This review describes the expression patterns of LIF and LIFR in bone, their regulation by physiological and inflammatory agents, as well as cell-specific influences of LIF on osteoblast, osteoclast, chondrocyte, and adipocyte differentiation. The actions of LIF in normal skeletal growth and maintenance, in pathological states (e. g. autocrine tumor cell signaling and growth in bone) and inflammatory conditions (e. g. arthritis) will be discussed, as well as the signaling pathways activated by LIF and their importance in bone formation and resorption.
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