Journal
GROWTH FACTORS
Volume 29, Issue 1, Pages 14-20Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/08977194.2010.533663
Keywords
-
Categories
Ask authors/readers for more resources
Various techniques and materials have been proposed for the treatment of periodontal defects. In periodontal regeneration, periodontal ligament (PDL) cell differentiation as well as certain growth factors and their delivery system applied are critical. The purpose of this study was to evaluate the in vitro effect of recombinant human transforming growth factor-beta 1 (rhTGF-beta 1) combined with two different bone grafts on human PDL (hPDL) cell differentiation. The hPDL cells were treated with TGF-beta 1 alone or in combination with a calcified freeze-dried bone allograft (FDBA) and a porous biphasic calcium phosphate (BC) bone graft. Cell differentiation effect was estimated by measuring alkaline phosphatase (ALPase) activity and osteocalcin secretion. Results demonstrated that rhTGF-beta 1 alone or in combination with FDBA and BC provoked a significant (p < 0.05) increase in ALPase activity as compared with controls. The findings of this study confirmed the beneficial role of rhTGF-beta 1 combined with FDBA and BC as carriers in periodontal regeneration.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available