Related references
Note: Only part of the references are listed.PET imaging of acute and chronic inflammation in living mice
Qizhen Cao et al.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2007)
Prognostic impact of KI67, p53, human epithelial growth factor receptor 2, topoisomerase IIα, epidermal growth factor receptor, and nm23 expression of ovarian carcinomas and disseminated tumor cells in the bone marrow
C. Schindlbeck et al.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER (2007)
EGF receptor is involved in WNT3a-mediated proliferation and motility of NIH3T3 cells via ERK pathway activation
Sung-Eun Kim et al.
CELLULAR SIGNALLING (2007)
Protein kinase Cα mediates feedback inhibition of EGF receptor transactivation induced by Gq-coupled receptor agonists
Chintda Santiskulvong et al.
CELLULAR SIGNALLING (2007)
MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
Jeffrey A. Engelman et al.
SCIENCE (2007)
Inhibition of ADAM17 reduces hypoxia-induced brain tumor cell invasiveness
Xuguang Zheng et al.
CANCER SCIENCE (2007)
Downregulation of erbB3 abrogates erbB2-mediated tamoxifen resistance in breast cancer cells
Bolin Liu et al.
INTERNATIONAL JOURNAL OF CANCER (2007)
Phase II randomized study of daily gefitinib treatment alone or with vinorelbine every 2 weeks in patients with adenocarcinoma of the lung who failed at least 2 regimens of chemotherapy
Yuh-Min Chen et al.
CANCER (2007)
Unligated epidermal growth factor receptor forms higher order oligomers within microclusters on A431 cells that are sensitive to tyrosine kinase inhibitor binding
Andrew H. A. Clayton et al.
BIOCHEMISTRY (2007)
Effect of epidermal growth factor receptor inhibitor class in the treatment of head and neck cancer with concurrent radiochemotherapy in vivo
Felix Y. Feng et al.
CLINICAL CANCER RESEARCH (2007)
ErbB3 expression and dimerization with EGFR influence pancreatic cancer cell sensitivity to erlotinib
Andrey Frolov et al.
CANCER BIOLOGY & THERAPY (2007)
Amphiregulin is an essential mediator of estrogen receptor α function in mammary gland development
Laura Ciarloni et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Dual EGFR and mTOR targeting in squamous cell carcinoma models, and development of early markers of efficacy
A. Jimeno et al.
BRITISH JOURNAL OF CANCER (2007)
The efficacy of epidermal growth factor receptor-specific antibodies against glioma xenografts is influenced by receptor levels, activation status, and heterodimerization
Terrance G. Johns et al.
CLINICAL CANCER RESEARCH (2007)
Stimulated ErbB4 internalization is necessary for neuregulin signaling in neurons
Yu Liu et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)
A phase I clinical trial with monoclonal antibody ch806 targeting transitional state and mutant epidermal growth factor receptors
Andrew M. Scott et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Discovery of a potent, selective, and orally active human epidermal growth factor receptor-2 sheddase inhibitor for the treatment of cancer
Wenqing Yao et al.
JOURNAL OF MEDICINAL CHEMISTRY (2007)
Targeting EGF-receptor-signalling in squamous cell carcinomas of the head and neck
C. W. M. Reuter et al.
BRITISH JOURNAL OF CANCER (2007)
Identification of a novel EGF-sensitive cell cycle checkpoint
Francesca Walker et al.
EXPERIMENTAL CELL RESEARCH (2007)
Lapatinib: a dual inhibitor of EGFR and HER2 tyrosine kinase activity
Filippo Montemurro et al.
EXPERT OPINION ON BIOLOGICAL THERAPY (2007)
Cetuximab in the treatment of metastatic colorectal cancer
Nicolas Moosmann et al.
EXPERT OPINION ON BIOLOGICAL THERAPY (2007)
Combined treatment of bladder cancer cell lines with lapatinib and varying chemotherapy regimens - Evidence of schedule-dependent synergy
Lynsey A. McHugh et al.
UROLOGY (2007)
Combining an mTOR antagonist and receptor tyrosine kinase inhibitors for the treatment of prostate cancer
David Masiello et al.
CANCER BIOLOGY & THERAPY (2007)
Therapeutic anti-EGFR antibody 806 generates responses in murine de novo EGFR mutant-dependent lung carcinomas
Danan Li et al.
JOURNAL OF CLINICAL INVESTIGATION (2007)
Targeting TACE-dependent EGFR ligand shedding in breast cancer
Paraic A. Kenny et al.
JOURNAL OF CLINICAL INVESTIGATION (2007)
Vandetanib (ZD6474): an orally available receptor tyrosine kinase inhibitor that selectively targets pathways critical for tumor growth and angiogenesis
Roy S. Herbst et al.
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2007)
Are exon 19 deletions and L858R EGFR mutations in non-small-cell lung cancer clinically different?
D. B. Costa et al.
BRITISH JOURNAL OF CANCER (2007)
Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3
Natalia V. Sergina et al.
NATURE (2007)
PTEN-mediated resistance to epidermal growth factor receptor kinase inhibitors
Ingo K. Mellinghoff et al.
CLINICAL CANCER RESEARCH (2007)
Ectodomain shedding of the EGF-receptor ligand epigen is mediated by ADAM17
Umut Sahin et al.
FEBS LETTERS (2007)
Progesterone receptor repression of prolactin/signal transducer and activator of transcription 5-mediated transcription of the β-casein gene in mammary epithelial cells
Adam C. Buser et al.
MOLECULAR ENDOCRINOLOGY (2007)
Genetic polymorphisms of the epidermal growth factor and related receptor in non-small cell lung cancer -: A review of the literature
Antonio Araujo et al.
ONCOLOGIST (2007)
Small molecule HER-2 tyrosine kinase inhibitors
Neil Spector et al.
BREAST CANCER RESEARCH (2007)
Breast cancer: The upgraded role of HER-3 and HER-4
Michalis V. Karamouzis et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2007)
Epidermal growth factor receptor-mediated signal transduction in the development and therapy of gliomas
M. Kelly Nicholas et al.
CLINICAL CANCER RESEARCH (2006)
Molecular mechanisms of epidermal growth factor receptor (EGFR) activation and response to gefitinib and other EGFR-targeting drugs
Mayumi Ono et al.
CLINICAL CANCER RESEARCH (2006)
ErbB receptors in fetal endothelium - A potential linkage point for inflammation-associated neonatal disorders
Wolfgang Bueter et al.
CYTOKINE (2006)
The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized
Mark F. van Delft et al.
CANCER CELL (2006)
Presenilin-dependent ErbB4 nuclear signaling regulates the timing of astrogenesis in the developing brain
S. Pablo Sardi et al.
CELL (2006)
Single-molecule analysis of epidermal growth factor binding on the surface of living cells
Yuji Teramura et al.
EMBO JOURNAL (2006)
The epidermal growth factor receptor pathway: A model for targeted therapy
Maurizio Scaltriti et al.
CLINICAL CANCER RESEARCH (2006)
EGFR signaling leads to downregulation of PTP-LAR via TACE-mediated proteolytic processing
Jens E. Ruhe et al.
CELLULAR SIGNALLING (2006)
Mammalian target of rapamycin inhibition promotes response to epidermal growth factor receptor kinase inhibitors in PTEN-Deficient and PTEN-intact glioblastoma cells
Maria Y. Wang et al.
CANCER RESEARCH (2006)
ErbB4 increases the proliferation potential of human lung cancer cells and its blockage can be used as a target for anti-cancer therapy
Alex Starr et al.
INTERNATIONAL JOURNAL OF CANCER (2006)
Phase I trial of erlotinib with radiation therapy in patients with glioblastoma multiforme: Results of north central cancer treatment group protocol N0177
Sunil Krishnan et al.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2006)
The role of the ErbB family members in non-small cell lung cancers sensitive to epidermal growth factor receptor kinase inhibitors
Jeffrey A. Engelman et al.
CLINICAL CANCER RESEARCH (2006)
Targeting ADAM-mediated ligand cleavage to inhibit HER3 and EGFR pathways in non-small cell lung cancer
Bin-Bing S. Zhou et al.
CANCER CELL (2006)
Improvement of psoriasis and cutaneous side-effects during tyrosine kinase inhibitor therapy for renal metastatic adenocarcinoma. A role for epidermal growth factor receptor (EGFR) inhibitors in psoriasis?
E Wierzbicka et al.
BRITISH JOURNAL OF DERMATOLOGY (2006)
Signaling through ERBB receptors: Multiple layers of diversity and control
CM Warren et al.
CELLULAR SIGNALLING (2006)
Constitutive activation of neuregulin/ERBB3 signaling pathway in clear cell sarcoma of soft tissue
Karl-Ludwig Schaefer et al.
NEOPLASIA (2006)
Signaling via ErbB2 and ErbB3 associates with resistance and Epidermal Growth Factor Receptor (EGFR) amplification with sensitivity to EGFR inhibitor gefitinib in head and neck squamous cell carcinoma cells
Kaisa Erjala et al.
CLINICAL CANCER RESEARCH (2006)
An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor
Xuewu Zhang et al.
CELL (2006)
Role of epidermal growth factor receptor pathway-targeted therapy in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck
Ezra E. W. Cohen
JOURNAL OF CLINICAL ONCOLOGY (2006)
Compensatory ErbB3/c-Src signaling enhances carcinoma cell survival to ionizing radiation
JN Contessa et al.
BREAST CANCER RESEARCH AND TREATMENT (2006)
Effect of dominant-negative epidermal growth factor receptors on cardiomyocyte hypertrophy
Hsiu-Wen Chan et al.
JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION (2006)
Tackling the EGFR in pathological tissue remodelling
HW Chan et al.
PULMONARY PHARMACOLOGY & THERAPEUTICS (2006)
EGF receptor mutations in lung cancer: From humans to mice and maybe back to humans
Carlos L. Arteaga
CANCER CELL (2006)
Adjuvant trastuzumab: A milestone in the treatment of HER-2-positive early breast cancer
Jose Baselga et al.
ONCOLOGIST (2006)
Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors
IK Mellinghoff et al.
NEW ENGLAND JOURNAL OF MEDICINE (2005)
Clinical significance of EGFR amplification and the aberrant EGFRVIII transcript in conventionally treated astrocytic gliomas
L Liu et al.
JOURNAL OF MOLECULAR MEDICINE-JMM (2005)
WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature
IB Lobov et al.
NATURE (2005)
Secretase-dependent tyrosine phosphorylation of Mdm2 by the ErbB-4 intracellular domain fragment
RR Arasada et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
GPCR-induced migration of breast carcinoma cells depends on both EGFR signal transactivation and EGFR-independent pathways
S Hart et al.
BIOLOGICAL CHEMISTRY (2005)
Treatment of human tumor xenografts with monoclonal antibody 806 in combination with a prototypical epidermal growth factor receptor-specific antibody generates enhanced antitumor activity
RM Perera et al.
CLINICAL CANCER RESEARCH (2005)
ERBB4/HER4 potentiates STAT5A transcriptional activity by regulating novel STAT5A serine phosphorylation events
DE Clark et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
An inhibitor of Bcl-2 family proteins induces regression of solid tumours
T Oltersdorf et al.
NATURE (2005)
Transforming growth factor alpha (TGF-α) and other targets of tumor necrosis factor-alpha converting enzyme (TACE) in murine polycystic kidney disease
R Nemo et al.
PEDIATRIC RESEARCH (2005)
ERBB receptors and cancer: The complexity of targeted inhibitors
NE Hynes et al.
NATURE REVIEWS CANCER (2005)
Critical update and emerging trends in epidermal growth factor receptor targeting in cancer
J Baselga et al.
JOURNAL OF CLINICAL ONCOLOGY (2005)
Negative regulation of EGFR signalling through integrin-alpha(1)beta(1)-mediated activation of protein tyrosine phosphatase TCPTP
E Mattila et al.
NATURE CELL BIOLOGY (2005)
Timeline - The discovery of receptor tyrosine kinases: targets for cancer therapy
A Gschwind et al.
NATURE REVIEWS CANCER (2004)
Cannabinoids induce cancer cell proliferation via tumor necrosis factor α-converting enzyme (TACE/ADAM17)-mediated transactivation of the epidermal growth factor receptor
S Hart et al.
CANCER RESEARCH (2004)
Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands
U Sahin et al.
JOURNAL OF CELL BIOLOGY (2004)
Phenotypic variation resulting from a deficiency of epidermal growth factor receptor in mice is caused by extensive genetic heterogeneity that can be genetically and moleculaidy partitioned
KE Strunk et al.
GENETICS (2004)
Epidermal growth factor receptor family (EGFR, ErbB2-4) in gliomas and meningiomas
U Andersson et al.
ACTA NEUROPATHOLOGICA (2004)
Distinct ADAM metalloproteinases regulate G protein-coupled receptor-induced cell proliferation and survival
B Schäfer et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Hijacking epidermal growth factor receptors by angiotensin II: new possibilities for understanding and treating cardiac hypertrophy
NJ Smith et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2004)
Distinct domains in the SHP-2 phosphatase differentially regulate epidermal growth factor receptor/NF-kappa B activation through Gab1 in glioblastoma cells
GS Kapoor et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Frequent overexpression of multiple ErbB receptors by head and neck squamous cell carcinoma contrasts with rare antibody immunity in patients
R Bei et al.
JOURNAL OF PATHOLOGY (2004)
Role of STATs as downstream signal transducers in Src family kinase-mediated tumorigenesis
CM Silva
ONCOGENE (2004)
Antitumor efficacy of cytotoxic drugs and the monoclonal antibody 806 is enhanced by the EGF receptor inhibitor AG1478
TG Johns et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Mice humanised for the EGF receptor display hypomorphic phenotypes in skin, bone and heart
M Sibilia et al.
DEVELOPMENT (2003)
An open-and-shut case? Recent insights into the activation of EGF/ErbB receptors
AW Burgess et al.
MOLECULAR CELL (2003)
Nuclear localization and possible functions of receptor tyrosine kinases
G Carpenter
CURRENT OPINION IN CELL BIOLOGY (2003)
ErbB-4: mechanism of action and biology
G Carpenter
EXPERIMENTAL CELL RESEARCH (2003)
Epidermal growth factor receptor: mechanisms of activation and signalling
RN Jorissen et al.
EXPERIMENTAL CELL RESEARCH (2003)
Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab
HS Cho et al.
NATURE (2003)
The crystal structure of a truncated ErbB2 ectodomain reveals an active conformation, poised to interact with other ErbB receptors
TPJ Garrett et al.
MOLECULAR CELL (2003)
EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization
KM Ferguson et al.
MOLECULAR CELL (2003)
Structure of the epidermal growth factor receptor kinase domain alone and in complex with a 4-anilinoquinazoline inhibitor
J Stamos et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor α
TPJ Garrett et al.
CELL (2002)
Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains
H Ogiso et al.
CELL (2002)
Ligand-induced, receptor-mediated dimerization and activation of EGF receptor
J Schlessinger
CELL (2002)
Structure of the extracellular region of HER3 reveals an interdomain tether
HS Cho et al.
SCIENCE (2002)
The metalloprotease Kuzbanian (ADAM10) mediates the transactivation of EGF receptor by G protein-coupled receptors
YB Yan et al.
JOURNAL OF CELL BIOLOGY (2002)
Epidermal growth factor receptor (EGFR) transactivation by estrogen via the G-protein-coupled receptor, GPR30: a novel signaling pathway with potential significance for breast cancer
EJ Filardo
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2002)
γ-Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase
CY Ni et al.
SCIENCE (2001)
Growth retardation, duodenal lesions, and aberrant ileum architecture in triple null mice lacking EGF, amphiregulin, and TGF-α
KL Troyer et al.
GASTROENTEROLOGY (2001)
Heregulin-dependent translocation and hyperphosphorylation of ErbB-2
WL Zhou et al.
ONCOGENE (2001)
An oncogenic epidermal growth factor receptor signals via a p21-activated kinase-caldesmon-myosin phosphotyrosine complex
MJ McManus et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Expression of ErbB receptors during pancreatic islet development and regrowth
MR Kritzik et al.
JOURNAL OF ENDOCRINOLOGY (2000)
Defects in pathfinding by cranial neural crest cells in mice lacking the neuregulin receptor ErbB4
JP Golding et al.
NATURE CELL BIOLOGY (2000)