Journal
GROWTH FACTORS
Volume 26, Issue 6, Pages 325-330Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/08977190802442070
Keywords
Choroid; beta-adrenergic receptors; growth factors; macular degeneration
Categories
Funding
- Juvenile Diabetes Research Foundation [2-2006-114]
- NIA [R01 AG027827-01A1]
- Research to Prevent Blindness
- NATIONAL INSTITUTE ON AGING [R01AG027827] Funding Source: NIH RePORTER
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Remodeling of the choroidal vasculature is a prominent factor in age-related macular degeneration. While many of the growth factors involved in this vascular remodeling are known, their regulation remains much less so. The hypothesis of the present study was that stimulation of human choroidal endothelial cells with the beta-adrenergic receptor agonist isoproterenol would lead to an increase in pigment epithelial derived factor (PEDF) and angiopoietin 1 (Ang1), markers of a stable vasculature. Protein levels of PEDF and Ang1 were significantly increased following stimulation with isoproterenol. However, isoproterenol also significantly increased protein levels of vascular endothelial cell growth factor, which is active during vasculature remodeling. These data suggest that beta-adrenergic receptor agonists are likely upstream of a number of growth factors implicated in ocular disease and have multiple effects on choroidal endothelial cells. Modulation of this signaling in the choroid may offer a new avenue for therapeutics.
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