4.8 Article

C(sp3)-C(sp3) bond formation via copper/Bronsted acid co-catalyzed C(sp3)-H bond oxidative cross-dehydrogenative-coupling (CDC) of azaarenes

Journal

GREEN CHEMISTRY
Volume 16, Issue 5, Pages 2428-2431

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c4gc00038b

Keywords

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Funding

  1. National Natural Science Foundation of China [21202138]
  2. Xiangtan University Academic Leader Program [11QDZ20]
  3. Ministry of Education [20124301120007, 201210530008]
  4. University Student Innovation Program
  5. Project of Hunan Provincial Natural Science Foundation [13JJ4047, 12JJ7002]
  6. Excellent Young Scientist Foundation of Hunan Provincial Education Department [13B114]

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A copper/Bronsted acid dual-catalyst promoted oxidative cross-dehydrogenative-coupling of alkylazaarenes and tertiary amines for C(sp(3))-C(sp(3)) bond formation was developed. This method uses dioxygen as the terminal oxidant under mild reaction conditions and would provide a convenient benzylic C-H transformation of alkylazaarenes to biologically active pharmaceutics.

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