Journal
GREEN CHEMISTRY
Volume 16, Issue 12, Pages 4914-4921Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4gc00411f
Keywords
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Funding
- Research Council of Iran University of Science and Technology (IUST), Tehran, Iran [160/771]
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An improved one-pot three-component and environmentally benign approach for the synthesis of a wide range of densely functionalized 2-amino-3-cyano-4H-pyran annulated derivatives has been described by the reaction of aryl aldehydes, malononitrile and diverse electron-rich phenolic or enolizable carbonyl compounds under mechanochemical ball milling conditions in the presence of potassium phthalimide (POPI), as a mild basic organocatalyst, at ambient temperature. In comparison to the conventional methods, the remarkable advantages of this green protocol are high to quantitative yields, avoiding the use of any hazardous transition metal-free catalyst or solvent, shorter reaction time at ambient temperature, low cost, and straightforward work-up procedure.
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