Journal
GREEN CHEMISTRY
Volume 15, Issue 5, Pages 1238-1243Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3gc36607c
Keywords
-
Funding
- [SFB 840]
Ask authors/readers for more resources
Traditional synthesis methods for propargylamines have several drawbacks. A recently developed alternative route is the so-called A(3) coupling in which an alkyne, an aldehyde, and an amine are coupled together. Typically, these reactions are catalysed by homogeneous gold salts, organogold complexes or silver salts. But these homogeneous catalysts are expensive and their separation is difficult. Here we report the discovery that solid Cu/Al/oxide mesoporous sponges are excellent A(3) coupling catalysts. These materials are robust, inexpensive, and easy to make. They give good to excellent yields (87-97%) for a wide range of substrates. Being heterogeneous, these catalysts are also easy to handle and separate from the reaction mixture, and can be recycled with no loss of activity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available