Journal
GREEN CHEMISTRY
Volume 15, Issue 2, Pages 453-462Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2gc36552a
Keywords
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Funding
- National Natural Science Foundation of China [81160384, 21162037, 21262042, U1202221]
- Natural Science Foundation of Yunnan Province [2009CC017, 2011Z042, 2009B08Q, K1050669, 2011J021, 2010120303]
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A concise and efficient one-pot regio- and stereoselective synthesis of structurally diverse spirooxindoles was constructed by simply refluxing a mixture of different types of heterocyclic ketene aminals, isatins and ethyl trifluoroacetate using catalytic piperidine. The advantages of this method include high efficiency, mild reaction conditions and environmentally benign reagents. These spirooxindoles are promising candidates for drug discovery; consequently, a library of diverse spirooxindoles was rapidly constructed using the present protocol.
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