Journal
KIDNEY & BLOOD PRESSURE RESEARCH
Volume 40, Issue 6, Pages 593-604Publisher
KARGER
DOI: 10.1159/000368535
Keywords
Blood pressure; Cardiovascular disease; Exercise; Haemodialysis; Inflammation
Funding
- Leicester Kidney Care Appeal
- National Institute for Health Research (NIHR) Diet, Lifestyle & Physical Activity Biomedical Research Unit based at University Hospitals of Leicester
- Loughborough University
- National Institutes of Health Research (NIHR) [CS-2013-13-014] Funding Source: National Institutes of Health Research (NIHR)
- National Institute for Health Research [CS-2013-13-014] Funding Source: researchfish
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Background/Aims: Patients requiring haemodialysis have cardiovascular and immune dysfunction. Little is known about the acute effects of exercise during haemodialysis. Exercise has numerous health benefits but in other populations has a profound impact upon blood pressure, inflammation and immune function; therefore having the potential to exacerbate cardiovascular and immune dysfunction in this vulnerable population. Methods: Fifteen patients took part in a randomised-crossover study investigating the effect of a 30-min bout of exercise during haemodialysis compared to resting haemodialysis. We assessed blood pressure, plasma markers of cardiac injury and systemic inflammation and neutrophil degranulation. Results: Exercise increased blood pressure immediately post-exercise; however, 1 hour after exercise blood pressure was lower than resting levels (106 +/- 22 vs. 117 +/- 25 mm Hg). No differences in h-FABP, cTnI, myoglobin or CKMB were observed between trial arms. Exercise did not alter circulating concentrations of IL-6, TNF-alpha or IL-1ra nor clearly suppress neutrophil function. Conclusions: This study demonstrates fluctuations in blood pressure during haemodialysis in response to exercise. However, since the fall in blood pressure occurred without evidence of cardiac injury, we regard it as a normal response to exercise superimposed onto the haemodynamic response to haemodialysis. Importantly, exercise did not exacerbate systemic inflammation or immune dysfunction; intradialytic exercise was well tolerated. (C) 2015 The Author(s) Published by S. Karger AG, Basel
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