4.8 Article

Direct aerobic oxidation of 2-benzylpyridines in a gas-liquid continuous-flow regime using propylene carbonate as a solvent

Journal

GREEN CHEMISTRY
Volume 15, Issue 2, Pages 320-324

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c2gc36896j

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Funding

  1. Christian Doppler Research Foundation (CDG)

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The use of high-temperature/pressure gas-liquid continuous flow conditions dramatically enhances the iron-catalyzed aerobic oxidation of 2-benzylpyridines to their corresponding ketones. Pressurized air serves as a readily available oxygen source and propylene carbonate as a green solvent in this radically intensified preparation of synthetically valuable 2-aroylpyridines.

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