4.8 Article

Ultrasound-promoted sterically congested Passerini reactions under solvent-free conditions

Journal

GREEN CHEMISTRY
Volume 14, Issue 11, Pages 3157-3163

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c2gc36095k

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Funding

  1. National Natural Science Foundation of China [21172124]
  2. National Basic Research Science Foundation of China [2010CB126105]
  3. National Key Technologies RD Program [2011BAE06B05]

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A facile, efficient and environmentally-friendly protocol for the synthesis of alpha-acyloxy amides has been developed by ultrasound-promoted sterically congested Passerini reactions under solvent-free conditions. This method provides several advantages over current reaction methodologies including a simpler work-up procedure, shorter reaction times and higher yields.

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