Journal
GREEN CHEMISTRY
Volume 14, Issue 2, Pages 290-295Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1gc16297g
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Funding
- CSIR-UGC, New Delhi
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An efficient L-proline catalyzed one-pot synthesis of 3-amino-alkylated indoles has been developed via a three-component Mannich-type reaction viz. secondary amines, aldehyde and indoles under solvent-free conditions at room temperature. Several amino acids (acidic, basic and neutral) have been screened for the reaction but the best results were obtained with L-proline.
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