4.8 Article

Fast, solvent-free and hydrogen-bonding-mediated asymmetric Michael addition in a ball mill

Journal

GREEN CHEMISTRY
Volume 14, Issue 4, Pages 893-895

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c2gc16521j

Keywords

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Funding

  1. Zhejiang Provincial Natural Science Foundation of China [Y4110373]
  2. Foundation of Zhejiang Education Committee [Y201018458]

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The chiral squaramide derivatives as hydrogen bonding catalyst for the Michael addition reactions of 1,3-dicarbonyl compounds to nitroolefins under solvent-free conditions was developed using a planetary ball mill. High yields, high enantioselectivities and shorter reaction times were achieved with low catalyst loading.

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