Journal
GREEN CHEMISTRY
Volume 13, Issue 8, Pages 2017-2020Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1gc15223h
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Funding
- CSIR New Delhi
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A grinding-induced catalyst- and solvent-free domino multicomponent reaction for the synthesis of 1,4-dihydropyridines has been developed using aldehydes, amines, DEAD (diethyl acetylenedicarboxylate), and malononitrile/ethyl cyanoacetate. The synthesized 1,4-dihydropyridines were efficiently converted into novel tacrine analogs 7a-7e using micelle-promoted microwave irradiation.
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