Journal
GREEN CHEMISTRY
Volume 13, Issue 1, Pages 185-189Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0gc00486c
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Funding
- CQ CSTC [2009BA5051]
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The unnatural ability of nuclease p1 from Penicillium citrinum was first discovered to catalyze asymmetric aldol reactions between aromatic aldehydes and cyclic ketones under solvent-free conditions. The excellent enantioselectivities of up to 99% ee and high diastereoselectivities of up to >99 : 1 (anti/syn) were achieved. This nuclease p1 catalyzed reaction provided a novel case for new activities of existing enzymes, which widens the applicability of this biocatalyst in organic synthesis.
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