Journal
GREEN CHEMISTRY
Volume 12, Issue 10, Pages 1803-1810Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0gc00076k
Keywords
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Funding
- CICYT [CTQ2008-00877, CTQ2008-04412]
- SENECA Foundation [08616/PI/08]
- Bancaja-UJI [P1-1B2009-58]
- CSIC [200980I092]
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The immobilisation of Candida antarctica lipase B (CALB) onto SILLPs has been studied in order to obtain the maximum activity, selectivity and stability of the resulting supported biocatalyst for the KR of rac-1-phenylethanol by flow processes using scCO(2). This involves the use of hydrophilic SILLPs (chloride anion) with high loadings of IL moieties and CALB. The combination of the immobilized biocatalyst with an acidic zeolite has allowed us to carry out DKR processes. Excellent results in terms of yield (92%) and enantioselectivity (>99.9% ee) are obtained by the use of a one-pot reactor containing a mixture of both catalyst particles under scCO(2) flow conditions (50 degrees C, 10 MPa), resulting in an environmentally friendly process with high productivity and enantioselectivity.
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