Journal
GREEN CHEMISTRY
Volume 12, Issue 11, Pages 2043-2052Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0gc00373e
Keywords
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Funding
- Natural Science Foundation of China [30860342, 20762013]
- Natural Science Foundation of Yunnan Province [2009CC017, 2008CD063]
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An efficient one-pot, three-component synthesis of highly substituted bicyclic pyridines containing a ring-junction nitrogen, starting from simple and readily available materials, is described. Cyclocondensation of heterocyclic ketene aminals (HKAs), triethoxymethane, and active methylene compounds by refluxing under solvent-free and catalyst-free conditions, provided bicyclic pyridines in excellent yields.
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