Journal
GREEN CHEMISTRY
Volume 12, Issue 2, Pages 216-219Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b913816a
Keywords
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Funding
- Natural Science Foundation of China [20672035]
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A simple, environmentally friendly, tandem Knoevenagel condensation and Michael addition procedure is reported. The reactions between cyclic-13-diketones and a variety of aldehydes were carried out in water to afford tetraketones (64-99%). In this green synthetic protocol, the solvent water itself catalysed the reaction by hydrogen bonding, thus avoiding the use of any other catalysts to make the work up procedure easier.
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