4.8 Article

Efficient copper-catalyzed N-arylations of nitrogen-containing heterocycles and aliphatic amines in water

Journal

GREEN CHEMISTRY
Volume 12, Issue 6, Pages 1097-1105

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c002172e

Keywords

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Funding

  1. National Natural Science Foundation of China [20672065, 20972083]
  2. Chinese 863 Project [2007AA02Z160]
  3. Beijing Department of Education [XK100030514]

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A simple and efficient copper-catalyzed method has been developed for N-arylations of nitrogen-containing heterocycles and aliphatic amines in water. The protocol uses (1E,2E)-oxalaldehyde dioxime (OADO) as the ligand, and water as the solvent, and shows good tolerance towards various functional groups.

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