4.8 Article

Green alcohol couplings without transition metal catalysts: base-mediated β-alkylation of alcohols in aerobic conditions

Journal

GREEN CHEMISTRY
Volume 12, Issue 8, Pages 1362-1364

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c0gc00079e

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Funding

  1. ACS-GCI Pharmaceutical roundtable
  2. DOE [DE-GF02-84ER13297]

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Benzylic secondary alcohols can be alkylated in good yields at the beta-position with primary alcohols promoted by KOH and NaOH, eliminating the need for toxic and expensive transition metal catalysts.

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