4.8 Article

Highly efficient chemoselective construction of 2,2-dimethyl-6-substituted 4-piperidones via multi-component tandem Mannich reaction in ionic liquids

Journal

GREEN CHEMISTRY
Volume 12, Issue 6, Pages 949-952

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b926498a

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Funding

  1. National Natural Science Foundation of China [20873179]
  2. Renmin University of China
  3. Hong Kong Research Grants Council [PolyU 5001/07P]
  4. Hong Kong UGC [AoE P/10-01]
  5. Hong Kong Polytechnic University

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The room temperature ionic liquid [bmim][PF6] has been demonstrated to be an efficient and recyclable medium for highly chemoselective synthesis of 2,2-dimethyl-6-substituted 4-piperidones via a L-proline catalyzed tandem Mannich reaction of ammonia, aldehydes and acetone, and good yields were achieved for aryl and alkyl aldehydes.

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