4.8 Article

Sonogashira coupling reactions in biodegradable ionic liquids derived from nicotinic acid

Journal

GREEN CHEMISTRY
Volume 12, Issue 4, Pages 650-655

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b919394d

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Funding

  1. Pfizer Global RD
  2. Spanish Ministerio de Educacion y Ciencia [CTQ2007-60364/PPQ]
  3. Australian Research Council [LX0561094]
  4. Natural Sciences and Engineering Research Council of Canada NSERC
  5. Australian Research Council [LX0561094] Funding Source: Australian Research Council

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The biodegradable ionic liquids, 3-butoxycarbonyl-1-methylpyridinium bis(trifluoromethanesulfonyl)imides (1a-d), have been evaluated as solvents for copper- and phosphine-free Sonogashira coupling reactions. The stability of these ionic liquids toward basic conditions was analysed in order to further probe their utility for transition metal catalyzed reactions which require the presence of a base.

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