Journal
GREEN CHEMISTRY
Volume 11, Issue 10, Pages 1633-1637Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b914286j
Keywords
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Funding
- NSFC of China [20775069]
- NSFC of Zhejiang province [Z206510]
- National Ministry of Education of China [NCET-06-0520]
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By applying water as the reaction medium, the one-pot synthesis of 1,2-disubstituted benzimidazoles has been achieved in excellent efficiency and selectivity at room temperature via trimethylsilyl chloride promoted reaction of o-phenylenediamine with aldehyde. This green catalyst system has also been successfully extended to the synthesis of quinoxalines via the reaction of o-phenylenediamine with alpha-bromoketone. Water displayed a specific functionality in mediating the selectivity, and remarkable advantages over organic solvents in terms of yields as well as in the work up procedure of the reactions.
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