Journal
GREEN CHEMISTRY
Volume 11, Issue 6, Pages 878-882Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b904655k
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A novel, environmentally friendly, tandem Knoevenagel condensation and mercaptoacetylative cyclisation procedure is reported. The reaction between 2-methyl-2-phenyl-1,3-oxathiolan-5-one and a variety of salicylaldehydes was carried out in water to afford 3-mercaptocoumarins in excellent yields (82-97%). In this green synthetic protocol, water itself catalyses the reaction by hydrogen bonding and thus avoids the use of any other catalyst. Acetophenone obtained as a by-product was also recovered and recycled easily for further use.
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