4.8 Article

Fast, quantitative nucleoside protection under solvent-free conditions

Journal

GREEN CHEMISTRY
Volume 10, Issue 6, Pages 627-628

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b801455h

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Funding

  1. Engineering and Physical Sciences Research Council [GR/T23145/01] Funding Source: researchfish

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Persilylation of nucleoside hydroxyls was effected in quantitative yields under solvent-free conditions using a ball mill. In addition, one-pot persilylation and acylation of cytidine was performed as an exemplar reaction demonstrating the utility of solvent-free approaches to nucleoside chemistry.

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