Journal
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
Volume 256, Issue 12, Pages 2309-2317Publisher
SPRINGER
DOI: 10.1007/s00417-018-4143-1
Keywords
Large choroidal vessel (Haller vessel); Pachyvessel; Age-related macular degeneration; Polypoidal choroidal vasculopathy; Central serous chorioretinopathy; Pachychoroid
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PurposeTo compare choroidal vascular characteristics of age-related macular degeneration (AMD), polypoidal choroidal vasculopathy (PCV), and central serous chorioretinopathy (CSC) by qualitative and quantitative analyses using swept-source en face optical coherence tomographic (OCT) images.MethodsEyes with non-neovascular AMD (n=32), neovascular AMD (n=30), thick and thin choroid PCV (n=33 and 27), and CSC (n=34) were enrolled. Subfoveal choroidal thickness (SFCT) and the presence and patterns of pachyvessels were assessed. En face images of the large choroidal vessel layer were converted to binary images for the analysis of vascular density.ResultsPachyvessels were identified in 8 (25%), 14 (46%), 28 (85%), 26 (96%), and 34 (100%) non-neovascular AMD, neovascular AMD, thin choroid PCV, thick choroid PCV, and CSC eyes, respectively (P<0.001). The pattern of pachyvessels was focal in non-neovascular AMD (100%), neovascular AMD (79%), and thin choroid PCV (89%) while the pattern was mostly diffuse in CSC (88%) and thick choroid PCV (81%). The mean choroidal vascular density in a 6x6mm(2) macular area of each group was 45.3%, 46.9%, 47.0%, 52.5%, and 54.8%, respectively (P<0.001). Post hoc analysis revealed significantly higher vascular density in CSC compared with other types (all P<0.001) except PCV with thick choroid (P=0.066).ConclusionsSimilarities in vascular density of the large choroidal vessel layer and pachyvessel pattern were between CSC and thick choroid PCV and between AMD and thin choroid PCV, suggesting common pathophysiology involving choroidal changes in these eyes.
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