Journal
GOLD BULLETIN
Volume 41, Issue 1, Pages 37-41Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/BF03215621
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In this work, we report the use of unmodified gold nanoparticles (AuNPs) as an optical probe for the detection of target-responsive structural variations of DNA. By employing two DNA structures, i.e., a pH-responsive i-motif oligonucleotide and a mercury-specific oligonucleotide (MSO), we demonstrated that AuNPs could selectively distinguish target-free and target-bound oligonucleotides via the characteristic surface plasmon resonance-associated red-to-blue color change. Based on these observations, we developed a convenient mix-and-detect approach that could selectively detect environmentally toxic mercury ions.
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