Journal
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
Volume 71, Issue 8, Pages 1022-1028Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/gerona/glv114
Keywords
p16INK4a; Cell senescence; Skin; Wrinkle; Elastic fiber
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Funding
- Innovation Oriented research Program on Genomics (SenterNovem) [IGE01014, IGE5007]
- Centre for Medical Systems Biology (CMSB)
- Netherlands Genomics Initiative/Netherlands Organization for Scientific Research [NGI/NWO 05040202, 050-060-810 [NCHA]]
- Unilever
- EU [FP6 036894]
- National Institute on Aging [NIA P01 AG031862]
- Netherlands Genomics Initiative [NCHA 050-060-810]
- NIH Training Grant in Mechanisms of Vascular Disease [T32HL007751]
- Cancer Research UK [16566, 22311] Funding Source: researchfish
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The numbers of epidermal and dermal p16INK4a positive cells were significantly associated with age-associated elastic fiber morphologic characteristics, such as longer and a greater number of elastic fibers. The p16INK4a positive epidermal cells (identified as primarily melanocytes) were also significantly associated with more facial wrinkles and a higher perceived age. Participants in the lowest tertile of epidermal p16INK4a counts looked 3 years younger than those in the highest tertile, independently of chronological age and elastic fiber morphology. In conclusion, p16INK4a positive cell numbers in sun-protected human arm skin are indicative of both local elastic fiber morphology and the extent of aging visible in the face.
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