Journal
GLIA
Volume 61, Issue 1, Pages 55-61Publisher
WILEY-BLACKWELL
DOI: 10.1002/glia.22379
Keywords
microglia; purinergic signaling; neuropathic pain; spinal cord
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Funding
- JSPS through CSTP
- JSPS through MEXT of Japan
- Canadian Institutes of Health Research (CIHR)
- Core-to-Core program of JSPS
- Krembil Foundation
- Ontario Research Foundation
- Canada research chair
- Howard Hughes Medical Institute
- Grants-in-Aid for Scientific Research [23229008] Funding Source: KAKEN
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Many pathological processes within the central nervous system are mediated by complex interactions between neurons and resident glial cells. In the case of painful peripheral neuropathy, spinal microglia react and undergo a series of changes that directly influence the establishment of neuropathic pain states. Purinergic signaling has been shown to be at the center of this reactivity, and here we review recent mechanistic advances describing the importance of microglial P2 receptors and their interactions with neuronal populations in the development of neuropathic pain. (c) Wiley Periodicals, Inc.
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