Journal
GLIA
Volume 59, Issue 8, Pages 1148-1154Publisher
WILEY
DOI: 10.1002/glia.21185
Keywords
glioma; cancer stem cell; therapy resistance
Categories
Funding
- National Brain Tumor Society
- Goldhirsh Foundation
- NIH [NS054276, CA129958, CA116659, CA154130]
- National Research Service [NS058042]
- Damon Runyon Cancer Research Foundation
- American Brain Tumor Association
- Canadian Cancer Society Research Institute
- Canadian Institutes for Health Research
- Ontario Institute for Cancer Research
- Terry Fox Foundation
- Hospital for Sick Children Foundation
- Jessica's Footprint Foundation
- National Cancer Institute
- National Institutes of Neurological Disorders, and Stroke/National Institutes of Health
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Neuro-oncology research has rediscovered a complexity of nervous system cancers through the incorporation of cellular heterogeneity into tumor models with cellular subsets displaying stem-cell characteristics. Self-renewing cancer stem cells (CSCs) can propagate tumors and yield nontumorigenic tumor bulk cells that display a more differentiated phenotype. The ability to prospectively isolate and interrogate CSCs is defining molecular mechanisms responsible for the tumor maintenance and growth. The clinical relevance of CSCs has been supported by their resistance to cytotoxic therapies and their promotion of tumor angiogenesis. Although the field of CSC biology is relatively young, continued elucidation of the features of these cells holds promise for the development of novel patient therapies. (C) 2011 Wiley-Liss, Inc.
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