Journal
GLIA
Volume 58, Issue 9, Pages 1017-1030Publisher
WILEY
DOI: 10.1002/glia.20983
Keywords
Cannabinoid; microglia; astrocyte
Categories
Funding
- NIH [DA 14486, DA 21285]
Ask authors/readers for more resources
CB1 and CB2 receptors are activated by a plethora of cannabinoid compounds, be they endogenously-produced, plant-derived or synthetic. These receptors are expressed by microglia, astrocytes and astrocytomas, and their activation regulates these cells' differentiation, functions and viability. Recent studies show that glial cells also express cannabinoid-like receptors, and that their activation regulates different cell functions, but also control cell viability. This review summarizes this evidence, and discusses how selective compounds targeting cannabinoid-like receptors constitute promising therapeutics to manage neuroinflammation and eradicate malignant astrocytomas. Importantly, the selective targeting of cannabinoid-like receptors should provide therapeutic relieve without inducing the typical psychotropic effects and possible addictive properties associated with the use of Delta 9-tetrahydrocannabinol, the main psychotropic ingredient produced by the plant Cannabis sativa (C) 2010 Wiley-Liss, Inc.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available