Journal
GLIA
Volume 57, Issue 7, Pages 703-713Publisher
WILEY
DOI: 10.1002/glia.20798
Keywords
glutamate; glutamate transporters; ceftriaxone; dihydrokainate; sensorimotor gating; PPI
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Funding
- MIUR
- Fondazione Giorgini
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We tested the hypothesis that glutamate transporter GLT-1 (also known as EAAT2) plays a role in the regulation of prepulse inhibition (PPI) of the acoustic startle reflex, a simple form of information processing which is reduced in schizophrenia. To do this, we studied PPI in rats treated with ceftriaxone (200 mg/kg/day for 8 days), an antibiotic that selectively enhances GLT-1 expression and activity. We showed that ceftriaxone-induced GLT-1 upregulation is associated with impaired PPI of the startle, that this effect is reversed by dihydrokainate, a GLT-1 antagonist, that GLT-1 expression correlates negatively with PPI, and that PPI normalizes when GLT-1a levels return to baseline. Our data indicate that, GLT-1 regulates PPI of the startle reflex. (C) 2008 Wiley-Liss, Inc.
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