Journal
GLIA
Volume 56, Issue 14, Pages 1541-1551Publisher
WILEY
DOI: 10.1002/glia.20767
Keywords
CMT; peripheral neuropathy; gene regulation; Pou3f1; Egr2; Sox10; Srebp
Categories
Funding
- National Institutes of Health [HD41590]
- NWO [Vici 918.66.616]
- BSIK Program of the Dutch Government (Stem Cells in Development and Disease) [BSIK 03038]
- European Union [FP7 NGIDD]
- Muscular Dystrophy Association
- Charcot-Marie-Tooth Association
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During late fetal life, Schwann cells in the peripheral nerves singled out by the larger axons will transit through a promyelinating stage before exiting the cell cycle and initiating myelin formation. A network of extra- and intracellular signaling pathways, regulating a transcriptional program of cell differentiation, governs this progression of cellular changes, culminating in a highly differentiated cell. In this review. we focus on the roles of a number of transcription factors not only in myelination, during normal development, but also in demyelination, following nerve trauma. These factors include specification factors involved in early development of Schwann cells from neural crest (SOX10) as well as factors specifically required for transitions into the promyelinating and myelinating stages (Oct6/Scip and Krox20/Egr2). From this description, we can glean the first, Still very incomplete, contours of a gene regulatory network that governs myelination and demyelination during development and regeneration. (C)2008 Wiley-Liss, Inc.
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