Journal
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
Volume 16, Issue 1, Pages 32-43Publisher
ZHEJIANG UNIV PRESS
DOI: 10.1631/jzus.B1400221
Keywords
Breast cancer; Hypoxia-inducible factor 1 (HIF-1); Metastasis
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Funding
- National Basic Research Program (973) of China [2014CB910604, 2012CB910104]
- National Natural Science Foundation of China [31171358, 31371429]
- Research Fund for the Doctoral Program of Higher Education of China [20133402110020]
- Fundamental Research Funds for the Central Universities in China
- Chinese Government
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Accumulating evidence has shown that the hypoxic microenvironment, which is critical during cancer development, plays a key role in regulating breast cancer progression and metastasis. The effects of hypoxia-inducible factor 1 (HIF-1), a master regulator of the hypoxic response, have been extensively studied during these processes. In this review, we focus on the roles of HIF-1 in regulating breast cancer cell metastasis, specifically its effects on multiple key steps of metastasis, such as epithelial-mesenchymal transition (EMT), invasion, extravasation, and metastatic niche formation. We also discuss the roles of HIF-1-regulated non-coding RNAs in breast cancer metastasis, and therapeutic opportunities for breast cancer through targeting the HIF-1 pathway.
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