Journal
GERONTOLOGY
Volume 61, Issue 4, Pages 327-335Publisher
KARGER
DOI: 10.1159/000368575
Keywords
Neurogenesis; Ageing; Hippocampus; Memory
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Funding
- German Research Foundation (DFG
- 'Die Rolle von in der Entwicklung geborenen und adult geborenen granularen Nervenzellen in der Diskriminierung von Kontexten') [SE 2374/1-1]
- DFG [SFB873]
- Federal Ministry of Education and Research (BMBF independent research group)
- German Cancer Research Center (DKFZ)
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New neurons are continuously generated and added to neural circuits in the adult brain. However, increasing age imposes changes in neural progenitor cells and their microenvironment that lead to a reduction of neurogenesis. Age-related decreased production of new neurons in the neurogenic dentate gyrus has been associated with memory impairments. Several mechanisms are known that might counteract this decline in cognitive functions. Here, we give an overview of ageing-related changes in neurogenesis in the brain of humans and rodents. We discuss possible causes for reduced neurogenesis with age, its consequences on cognition, and how neurogenesis might be restored in old age. (C) 2014 S. Karger AG, Basel
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